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Creators/Authors contains: "Marcheschi, Michael"

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  1. (, ISU ReD: Research and eData)
    Meiotic drive elements, sometimes called selfish genes, are genetic elements that are passed on to their offspring more favorably than other genes. Meiotic drive elements have been observed in many organisms, including fungi of the Neurospora genus. Three different meiotic drive elements, called Spore killers, have been identified in Neurospora fungi. One of these Spore killers is called Spore killer 3 (Sk-3), and the molecular mechanism by which Sk-3 acts as a meiotic drive element is poorly understood. Previous work has identified a genetic locus within Sk-3 that may control spore killing. In this thesis, I investigate an interval of DNA within this locus called v375. Through gene deletion and spore killing assays, I show that deletion of v375 disrupts Sk-3-based spore killing in N. crassa. Possible explanations for why interval v375 is required for spore killing by Sk-3 are discussed. 
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